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THE INVENTION OF CHEMICAL COMPOUNDS OF HERBAL MEDICINE CONTAINING PIRIDINE FOR CORONA VIRUS (COVID – 19, MERS), HIV/AIDS, AND HEPATITIS

Author : Arend L. Mapanawang*, Sarah Mapanawang, Averous Budiadji, Frangkie Mapanawang, Amanda Manitik, Dewi Eriyanti, Silvister Wungow, Ismail, Dolfina Galela, Giovani Mapanawang, Maykel Kiling, Arthur E. Mongan, Blacius Dedi

Abstract

Drugs that many currently developed progressing well from natural materials and structures, quite a long period of 25 years, especially drugs for the inhibition of virus Corona, HIV / AIDS, a retrovirus (ARV) drugs such as Lamivudine and Generative her yet retrovirus capable of completely killing, is still limited to inhibiting (inhibition) for this paper to compare the strength of inhibition between drugs derived from chemical structures and Herbs. Research in the Tobelo year period 2014-2019 in STIKMAH Tobelo involving several laboratories such as the Laboratory of DKI, LIPI Laboratory, Laboratory of IPB Bogor and Others. Provide a reference for researchers, especially in the field of Pharmaceutical Chemistry, Nanomedicine and foremost also for WHO that supplements should not be underestimated and there is no benefit. Derived supplement China today is recognized as the world a malaria drug. Results found among other things that the power of the drugs inhibit retrovirus Lamivudine reached 46% while Golobe (Zingiberaceae) 43% and leaves Pangi reached 94.80%. This needs to be the seriousness of the world because there does not already over 45 million HIV / AIDS patients awaiting life-style drugs to raise expectations, as well as comparisons between Golobe and Lamivudine 46.75% inhibition and as anti-toxins, which also has the benefit of preventing golobe poison. Inhibition of RNA viruses, Corona Handling Family (COVID-19 mers) HIV / AIDS and Hepatitis. Compounds - compounds in Golobe2,3-Dihydro-3,5-Dihydro-6-methyl (5:31%), 2-formyl-5-isopropyl-8-Methylspiro (2.22%), 2,6-Diethylpyridine (5.88%), Cholest-5-en-3-one, 4,4-dimethyl (6.08%), hexadecanoic acid, ethyl ester (43%). The compound contained in the leaves of Pangi 3R-acetamido-IC, 6C-bis (acetoxy) 5T-dimethyl-Cyclohexene lamino (1:03%), (+) - 2-endo, 3-endo-dimethylbornane (1.24%), 3 , 5-dimethyl-1-dimethyl dodecyl silyl oxy benzene (1.62%), 2- (1-methyl-1,5,6,7-tetrahydro benzo pyrazole-3-yl) -6- (2-methyl-4,5,6, 7- tetrahydro benzo pyrazole-3-yl pyridine (2.59%), Phytol (10.33%), Squalene Dimethylamino (21.22%) (94.80%), red sea star-containing compoundButanoic acid, 3-methyl (13.64%), 2-piperidone (27.24%), 2-hydroxy-3,5,5-trimethyl-cyclohex-2-Enone 28 682 (6.79%), 3 -ISOBUTHYLHEXAHDROPYPROLO [1,2-a] pyrazine (1.87%), hexadecanoic acid (8.51%), 9.17-Octadecanienal, (Z) - (16.47%), Octadecanoic Acid (6.23% ), 9,12-Octadecadicnoic acid (z, z) - (5.73%), (6Z, 9z) -6.9-Pentadecadien-1-OL (1.95%), 6-Octadeccenoic acid. (4, 85%). A comparison between herbal ingredients more strongly inhibits the virus such as Corona Virus (COVID-19). Pangi leaves of chemical drug Lamivudine, while golobe has the same strength as well as inhibits virus lamivudine COVID-19 mers, HIV and Hepatitis. Golobe, Pangi, Piridine, inhibition of RNA, Corona Virus (COVID-19).

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