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EFFECT OF TONGKA LANGIT BANANA JUICE TO IMMUNE RESPONSE MICE MODEL OF MALARIA THROUGHTHE LEUKOCYTES DIFFERENTIAL OBSERVATION

Author : Efraim Samson*, Gremeldy Anggraeni Manunay, Chomsa Dintasari Umi Baszary

Abstract

Leukocytes are the cells of the immune system that consist of two main types, granulocytes and agranulocytes. These types involved in protecting human body against infectious disease and foreign invaders, including Plasmodium. The aim of this research is to find out the effect of tongka langit banana (Musa troglodytarum) juice on immune response mice (Mus musculus) model of malaria through the leukocytes differential observation. The research used Completely Randomized Design (CRD) with three replications. There are a total samples of 20 healthy male laboratory mices strain Balb/C, aged and weigh at ± 2 months and ± 20 gr. The samples consist of 5 donor mices and 15 treatment mices which divided into 5 groups namely K1 or normal control (not infected with Plasmodium berghei and not treated with tongka langit banana juice treatment); K2 or negative control (infected with Plasmodium berghei and no tongka langit banana juice treatment); and groups that are infected with Plasmodium berghei and treated with different dosage of tongka langit banana juice treatment at 0.55 gr/mice/day (K3); 0.65 gr/mice/day (K4); and 0.75 gr/mice/day (K5). The research found that tongka langit banana juice treatment affect leukocytes differential of lymphocytes parallel to the increased tongka langit banana juice dosage given. Whereas for the neutrophils and monocytes,the average percentage tend to decrease. Of the three different given dosages, the highest dosage at 0.75 gr/mice/day shown the most effective treatment. Key words: Leucocytes Differential, Malaria, Tongka Langit Banana.

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