Author : Anita Soraya Soetoko, Azizah Hikma Safitri, Israhnanto Isradji, Koko Agung Tri Wibowo, Avicennia Nandira, Dikta Zanwar Arifin Rafiq, Salma Savita, Ahmad N Al-Baari, Yoyok Budi, Dina Fatmawati*
Aims: Antidiabetic effect of Inulin from Dioscorea esculenta tubers in streptozotocin-induced diabetic rats was investigated. Methods: Antidiabetic effect was assessed based on HbA1C level, creatinine level, urea level, and microbiota composition in fecal. Level of HbA1C was determined using spectrophotometry. Level of creatinine and urea in blood serum was determined using enzymatic assay. The colony number of Bifidobacterium sp and Lactobacillus sp was evaluated using the total plate count method. Result: After 14 days of treatment, there was a significant difference between control and inulin-treated groups in the level of HbA1C, creatinine, and urea. The colony numbers of Bifidobacterium sp and Lactobacillus were higher in inulin-treated groups than those of control group (p<0.05). Conclusion: Inulin from Dioscorea esculenta tuber can be used as antidiabetic agent. Key words: Inulin, Dioscorea esculenta, antidiabetic effect.
Dr. Arend L Mapanawang, Sp.PD, FINASIM, PhD