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COMBINATION TREATMENT THE BEST MANAGEMENT OF MALARIA IN INDONESIA

Author : Arend L. Mapanawang

Abstract

Malaria is still one of deadly diseases worldwide since half of its population risks on the malaria. In 2008, the infection caused 863.000 deaths globally. In Indonesia, about 35% of people lives here and 38,000 people was reported died each year because of the plasmodium falciparum malaria. Genetic factor then is one of significant drug distributions where the gene acting in protein and enzyme coding influences the drug namely absorption, distribution, metabolism, and elimination (ADME). The purpose of this research is to know the profile of combination pharmacokinetic of DHA, piperaquine and primaquine in the falciparum malaria without complicated, relation of drug content, Cmax (peak content) and parasite clearance with DHA (Dehydroartemisinin), piperaquine and primaquine combination and its pharmacology effect that is therapy, side effect, and therapy failure on falciparum malaria without complicated in Halmahera. The research conducts randomly clinical test with experimental method in order to know pharmacokinetic combination of DHA, piperaquine, primaquine and its pharmacology effect to falciparum malaria before and after distribution of ACT theraphy (Artemycine Combination Therapy) toward 12 patients of falciparum malaria. Key words: Falciparum malaria, pharmacokinetic, DHA, Piperaquine, Primaquine, Parasite Clearance, APCR

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