Author : Arend L. Mapanawang
The treatment pattern of various diseases is still oriented toward approach to body weight and dosage in milligrams, or mg/ kgw. Various problems arise, such as side effects, toxicity, and drug resistance. It is recognized that the entry of the drug into the body can be affected by several factors such as genes, race, gender, age, and weight. These factors are closely linked to the pharmacokinetics of drugs that include absorption, distribution, metabolism, and elimination stages (ADME). 1 Research on genes and the ABO blood group shows that there are differences in the pharmacokinetics of each type of medication with each blood type.2 The treatment approach based on ABO blood type can increase the effectiveness of therapy and reduce side effects, toxic effects, and resistance on each individual. Currently, the treatment pattern generally provides the same dose to all blood types. In that regards, various diets based on blood types have also been developed. In the future, research should be developed towards the field of biomolecular, genes, and ABO blood group so that the pattern of disease treatment can target appropriate organ, with appropriate dosage, and with minimum side effects, toxicity and resistance, so that each individual receiving treatment is actually healing and safe from the adverse effects of the drug.
Dr. Arend L Mapanawang, Sp.PD, FINASIM, PhD