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THERAPEUTIC EFFECTS OF HERBS ON MYCOBACTERIUM TUBERCULOSIS: A SYSTEMATIC REVIEW

Author : Maedeh Sharghi, Zeynab Aminzadeh, Damoon Ashtary-Larky, Mohammad Firoozbakht, Bashir Mohamadpour, Majid Asadi-Samani*

Abstract

Mycobacterium tuberculosis is one of the agents responsible for tuberculosis in human and animals. This bacterium damages the lungs, central nervous system, lymphatic system, and blood circulating system. The aim of this study was to provide information about the herbs which are effective on Mycobacterium tuberculosis. In order to gather the information, keywords of “extract”, “plants” and “Mycobacterium tuberculosis” were searched in scientific databases including ScienceDirect, Pubmed, Scopus, Medline, SID, Iranmedex, and Medlib. In vivo and in vitro studies were included. 380 articles were collected in general. After exclusion of non-relevant and repetitive articles, 24 herbs were studied in this review. Effective herbs have shown their antibacterial effects through mechanisms such as increasing inflammatory cytokines like IFN-γ, IL-12, regulating the balance between Th1/Th2 and leading this ratio toward Th1, disturbing transcription from SP1 gene in promoter region of TACO regulatory gene and decreasing its expression, disturbing the ion balance in bacterial membrane and forming pores in the two- plants could provide scientists who work on medicine and treatment with useful information. Key words: Tuberculosis, Drug resistance, Natural products, Inflammation.

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