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LIPID VESICLES PHYSICAL PROPERTIES AND APPLICATION AS NANOCARRIERS IN DRUG DELIVERY SYSTEMS

Author : Philipus J. Patty* and Synodalia C. Wattimena

Abstract

Lipid vesicles are nano spherical containers made from lipid molecules. The formation of vesicles is due to the nature of lipid molecules, which have hydrophilic and hydrophobic parts. When they are exposed to an aqueous environment, the hydrophobic parts will hide from the water, while hydrophilic part will face the water. As a consequence, they will form a bilayer, and eventually enclose to a vesicle. The varieties of lipid molecules available for vesicle compositions enrich them to have a wide range of physical properties, including the fluidity, permeability, and the strength. To be used as nanocarriers in drug delivery system, lipid vesicles should have ability to contain the drugs and deliver them directly to the targeted site in the body. Lipid vesicles have advantageous to be used as nanocarriers in drug delivery system since they are biocompatible, they can encapsulate both hydrophobic and hydrophilic drug, and they can be modified by combination with other materials such as polymers and ligands to face biology challenges in the body. Key words: Vesicle, liposome, nanocarriers, lipid bilayer, drug delivery.

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