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LANGERHANS ISLET CELLS REGENERATION IN TYPE-1 DM MICE (Mus musculus) TREATED WITH METHANOL EXTRACT OF GAYAM (Inocarpus edulis Forst) STEM BARK

Author : Pieter Kakisina*, Alvisahry, Rosiana Rehiara

Abstract

Type-1 diabetes mellitus (Type-I DM) is a metabolic disorder caused by a deficiency of the insulin hormone due to the destruction of pancreatic  cells. The active compound in the bark of gayam tree (Inocarpus edulis Forst) extracted with methanol is thought to regenerate -cells on pancreatic Langerhans island in M. musculus with Type-1 DM. Mice weighing ± 20 g were divided into 4 treatment groups. Each group consisted of 3 mice. Furthermore, each group was induced with streptozotocin in a dose of 500 mg/50 ml in 0.02 M buffer citrate at 1 ml/g BW interperitoneally for 28 days. Blood sugar levels were measured every week using glucotest. Type-1 DM mice were treated with methanol extract of bark in doses of 0.4; 0.8 and 1.6 ml/g BW daily for 2 weeks. The results showed that methanol extract from the bark of Inocarpus edulis Forst tree was able to regenerate pancreatic -cells of the diabetic mice so that the glucose content decreased. Saponin and flavonoid compounds in the bark of Inocarpus edulis Forst have hypoglycemic effect that can lower blood sugar levels and regenerate pancreatic -cells. Key words: Regeneration, Pancreatic -Cells, Bark Of Inocarpus Edulis Forst.

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