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IDENTIFICATION OF FUNCTIONALAL GROUPS IN URINE OF DIABETES MELLITUS (DM) TYPE II PATIENTS USING INFRARED SPECTRUMETER

Author : Diana J Patty*, Grace Loupatty, Valentino Ulate

Abstract

A preliminary study was performed to identify functional groups in urine of diabetes mellitus (DM) type II patients. In this research, samples of DM patients were compared with non-DM samples. Sample test is done on the urine of fasting and urine 2 hours after eating, and tested its sugar level content. The test results of urine samples with IR spectrometer FTIR Type MB3000 ABB in Solid Physics Laboratory showed that, DM patients were identified on samples Fasting urine was alcohol functional group (OH stretch, 3200 -3650 cm-1), functional group Alkene (CH stretch, 2800-2900 cm-1), Carbon Dioxide functional groups (C≡C and C≡N, 2350 cm-1), and Amide functional groups (CO Stretch, 1650-1690 cm-1). Fasting sugar level 239 ml /dl. For the urine Samples 2 hours after meals, the functional groups of Alcohol (OH stretch, 3200-3650 cm-1), Alkene functional groups (CH Stretch, 2850-3000), Carbon Dioxide functional groups (C≡C and C≡N, 2350 cm-1), Alkene functional groups (C≡C, 2100-2210 cm-1), Amide functional groups (C = O, 1640-1670 cm-1), Alkene functional groups (CH bend, 1450-1470 cm- 1), and the functional group of Esters, (CO Stretch, 1000-1300 cm-1). And sugar levels 2 hours after eating 408 ml / dl. In non-DM samples, the samples of Fasting Urine (blood sugar level 100 ml / dl) and urine 2 hours after meal (blood sugar level 140 ml / dl), did not show significant differences, tended to be same functional and absorbance, Alcohol functional groups (OH stretch, 3200-3650 cm -1), Carbon Dioxide functional groups (C≡C and C≡N, 2350 cm-1), and Amide functional groups (C = O, 1640-1670 Cm-1). Significant differences in both DM and non-DM samples were identified in the presence of an alkene-functional group (CH Stretch, 2850-3000), Alkene functional groups (C≡C, 2100-2210 cm-1), Alkene functional groups (CH bend, 1450 -1470 cm-1), and the functional group of Esters, (CO Stretch, 1000-1300 cm- 1). Other things quite different on the Amide functional (C = O, 1640-1670 cm-1), although appearing in both samples, the highest absorbance values are in urine samples during DM patients, compared with DM. Key words: Functional Groups, Diabetes Mellitus, Ir Spectrum, Blood Sugar Levels.

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