EDITOR BOARD MEMBERS : VIEW ALL
Dr Bikasih Thapa & Dr Maheswar Prasad (Nepal) - Hideo Wada MD PhD (japan) - Dr a Lavra Castrocatesana (Mexico) - Dr Mrs N.M. Hettiarachechui (Srilanka) - Dr Jorge Aldrete Velasco (Mexico) - Prof Hans Peter Kohler (Switzerland) - Dr Hermanus Suhartono S Sp.OG(K) PhD - Dr Isabel Pinheiro (Portugal) - Dr Suranga (Srilanka) - Jovia Dino Jansen Amsterdam,Holand - Hideo Wada MD PhD University Graduate School of Medicine Departement of Moleculer and Laboratory Medicine Japan - DR Bikash Thapa Internal Medicine Nepal University - DR Maheswar Prasad Internal Medicine Nepal University - Dr a Lavra Castro Castresana Colegio de Medicina interna de Mexico - Dr Suransa Manilgama University of Srilanka Internal Departement Medicine - Dr Mrs N.M. Hettiarachechui University of Medicine Srilanka - Dr Jorge Aldrete Velaso .Colegio de Medicina Interna de Mexico - Prof Hans Peter Kholer M.D FACD Profesor of Medicine University ot Switzerland - Dr Ramezan Ali Atace . Baqiyatallah University of Medical Sciences Departement of Micrology Tehran Iran - Ezekiel Wong Toh Yoon Dr. Gastroenterology of Japan - D Eric Beck,MD Bethesda Hospital Capitol Boelevard St Paul USA - Dr Emine Guderen Sahin Istambul University of Internal Medicine Turky - Dr Selmin Toplan Istambul University - Dr Nicholas New Australia - Dr Kughan Govinden. Tropical Infection of Internal Medicine Malaysia - Dr Godfrey M Rwegerera Princes Marina Hospital Bostwana -
THE ROLE OF PRESEPSIN, C-REACTIVE PROTEIN AND PROCALCITONIN AS A MARKER OF THERAPY RESPONSE AND PROGNOSIS FOR LATE ONSET NEONATAL SEPSIS IN PRETERM NEONATES

Author : Dalima AW Astrawinata*, Risma Kerina Kaban, Rosalina Dewi Roeslani, Erna Parmawati

Abstract

Introduction : C-reactive protein (CRP) and procalcitonin (PCT) are the most widely used diagnostic and monitoring markers of neonatal sepsis. There is currently a new sepsis marker, Soluble CD14 subtype (sCD14-ST) presepsin. This study aims to determine the benefits of serial serum presepsin examination, CRP and PCT as well as the correlation between presepsin levels with CRP and PCT levels as a marker of therapy response and prognosis of late-onset neonatal sepsis (LONS) in preterm neonates. Method : This is a prospective cohort study. The subjects consisted of 40 healthy preterm neonates and 40 preterm neonates with LONS whose presepsin, CRP and PCT levels are going to be examined and monitored on the 3rd and 6th day of LONS after treatment. Preterm neonatal patients with LONS were divided into two groups, 20 neonates who are responsive to therapy and the other 20 who are non-responsive to therapy. The mortality of the preterm neonates with LONS is determined at day 30 monitoring. Results : The median levels of presepsin, CRP and PCT in preterm neonates with LONS were 1559 pg / mL (427 - 4835 pg / mL), 16.35 mg / L (0.1 - 245.6) and 4.11 ng / mL (0.17 - 54.18) respectively which were significantly higher than in healthy preterm neonates 406 pg / mL (195 - 562 pg / mL), 1.22 mg / L (0.1 - 3.69) and 0.03 (0.01 - 0.04) with p <0.05. The median levels of presepsin, CRP and PCT in LONS preterm neonates on the 3rd and 6th day, was significantly lower in the responsive to therapy group compared to the non-responsive to therapy group (p <0.05). The median levels of presepsin days 3 and 6 in the non-survivor group were significantly higher than in the survivor group (p <0.05) whereas the median CRP and PCT levels in the non-survivor group were significantly higher than the survivor group (p < 0.05) only on the 6th day after therapy. Presepsin levels did not correlate with CRP and PCT levels on day 3 and day 6 after therapy in both responsive to therapy and non-responsive groups (p> 0.05). The cut-off point of presepsin, CRP and PCT on the 6th day after therapy was determined for the prognosis of preterm neonates with LONS, with the highest area under the curve (AUC) was presepsin, PCT and CRP consecutively. Conclusion : Presepsin is the earliest and best-performing marker of sepsis for the prognosis of preterm neonatal mortality when compared to CRP and PCT. Key words: Presepsin, C-Reactive Protein, Procalcitonin, Late-Onset Neonatal Sepsis (LONS).

[ PDF ]

 

Indexing

;;;;;;;;

 

PENGUNJUNG KAMI DARI BERBAGAI BELAHAN DUNIA

Flag Counter