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ASSESSMENT OF LEUKOCYTE FILTERS EFFECTIVENESS ON PACKED RED CELLS

Author : Thoeng Ronald*, Ina S. Timan, Astuti Diantini, Bettia Bermawi, Rudianto

Abstract

Introduction : Removing leukocytes from donated blood is crucial for eliminating the risk of pathogen transmission, febrile non-hemolytic transfusion reactions, and various other transfusion side effects. Filtration using commercial polyurethane or polyester filters is the most common method of leukocyte removal from blood. This study examines and compares the efficiency of two commercial filters in removing leukocytes from packed red cells (PRC). Methods : This cross-sectional study utilized sixty bags of PRC collected from RSCM between 1-31 March 2014. Thirty bags each were filtered using Imugard® (Filter I) and BPF4® (Filter B). Samples were drawn from the PRC bags before and after filtration for hematology assessment. Complete blood count, including leukocyte counting, was done using an automatic cell counter (Sysmex XN-2000, Japan). Independent t-test was used to compare pre-filtration hematologic profiles of PRC bags in the two groups (I and B). Wilcoxon Signed-Rank test was used to test the difference in leukocyte content pre- and post-filtration for each filter, and percent leukocyte reduction between the two filters. Results : Prefiltration leukocyte content were similar in both groups of PRC (p=0.051). Both Filters I and B successfully filtered >99.9% leukocyte from blood, with Filter B slightly better by 0.03% (p=0.003). Leukocytes remaining after filtration were polymolphonuclear cells. Conclusion : Commercial filters Imugard® and BPF4® effectively reduces leukocyte content from packed red cells. Both filters could be used for filtering donated blood prior to transfusion, especially for patients who need repeated transfusions. Leukocyte Filter, Transfusion Side Effects, Packed Red Cells.

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